n-Amyl acetate

CAS number . . . . . . . . . . . 628-63-7
NIOSH REL. . . . . . . . . . . . 100 ppm (525 mg/m3) TWA
Current OSHA PEL . . . . . . . . 100 ppm (525 mg/m3) TWA
1989 OSHA PEL. . . . . . . . . . Same as current PEL
1993-1994 ACGIH TLV. . . . . . . 100 ppm (532 mg/m3) TWA
Description of substance . . . . Colorless liquid with a persistent
                                 banana-like odor.
LEL. . . . . . . . . . . . . . . 1.1% (10% LEL, 1,100 ppm)
Original (SCP) IDLH. . . . . . . 4,000 ppm
Basis for original (SCP) IDLH. . The chosen IDLH is based on the statement by
                                 Browning [1965] that exposure to 4,000 ppm of
                                 a mixture of n-amyl acetate and isoamyl
                                 acetate produced complete loss of reflexes in
                                 rabbits within an hour [Koelsch 1912], and on
                                 the statement by Sax [1975] that 5,000 ppm
                                 n-amyl acetate produced deep narcosis in cats
                                 in 30 minutes.
Short-term exposure guidelines . None developed
ACUTE TOXICITY DATA

Lethal concentration data: 



                                                       Adjusted               
                             LC50    LCLo               0.5-hr         Derived
Species     Reference       (ppm)   (ppm)    Time       LC (CF)         Value
______________________________________________________________________________
Rat      NPIRI 1974         -----   5,200     ?            ?              ?   

Lethal dose data:

                                                                              
                                    LD50     LDLo                      Derived
Species     Reference      Route   (mg/kg) (mg/kg)     Adjusted LD      Value
______________________________________________________________________________
Rabbit   Marhold 1986       oral    7,400   -----      9,575 ppm       958 ppm
Rat      NPIRI 1974         oral    6,500   -----      8,410 ppm       841 ppm

                                  
Other animal data. . . . . . . . RD50 (mouse), 1,531 ppm [Alarie 1981].
Human data . . . . . . . . . . . Somnolence has been reported after exposure
                                 to 952 ppm for 30 minutes [Lehmann 1913].




Revised IDLH: 1,000 ppm
Basis for revised IDLH: The revised IDLH for 
n-amyl acetate is 1,000 ppm based on acute toxicity data in humans [Lehmann 
1913] and animals [Alarie 1981; Marhold 1986]. 

REFERENCES:


    
  
  1. Alarie Y [1981]. Dose-response analysis in animal studies: prediction of 
  human responses. Environ Health Perspect 42:9-13. 
  
  2. Browning E [1965]. Toxicity and metabolism of industrial solvents. New 
  York, NY: Elsevier Publishing Company, p. 539. 
  
  3. Koelsch [1912]. Damage to health by amyl acetate. Concordia No. 12. 
  
  4. Lehmann KB [1913]. Experimentelle studien uber den einflufs technisch 
  wichtiger gase und dampfe auf den organimus (XXXII/XXXIII). Amylazetat und 
  cyclohexanolazetat. Arch Hyg 78:260-273 (in German). 
  
  5. Marhold J [1986]. Prehled prumyslove toxikologie: organicke latky. Prague, 
  Czechoslovakia: Avicenum, p. 357 (in Czechoslovakian). 
  
  6. NPIRI [1974]. Raw materials data handbook, physical and chemical 
  properties, fire hazard and health hazard data. Vol. 1. Organic solvents. 
  Bethlehem, PA: National Printing Ink Research Institute, p. 3. 
  
  7. Sax NI [1975]. Dangerous properties of industrial materials. 4th ed. New 
  York, NY: Van Nostrand Reinhold Company, Inc., p. 398. 



Go back to the Documentation for Immediately
Dangerous To Life or Health Concentrations
(IDLHs)